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期刊论文 43

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CO2捕集 1

两亲高分子 1

串联链路 1

亲水 1

免疫抑制 1

共混微孔膜 1

关键技术 1

再生混凝土 1

初轨确定算法；单X射线脉冲星探测器；相位增量；二体运动方程；加权最小二乘法 1

区间二型模糊控制器；解析结构；Karnik-Mendel降型 1

原生混凝土 1

发展趋势 1

可持续发展 1

可靠度 1

含钒钢渣 1

固溶体 1

基础研究 1

多联产 1

奈奎斯特采样定理；亚奈奎斯特采样；最小欧式距离；欠定线性问题；时变维特比算法 1

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Analysis of statistical thermodynamic model for binary protein adsorption equilibria on cation exchange adsorbent

ZHOU Xiaopeng, SU Xueli, SUN Yan

《化学科学与工程前沿（英文）》 2007年 第1卷 第2期   页码 103-112 doi: 10.1007/s11705-007-0020-x

摘要： A study of nonlinear competitive adsorption equilibria of proteins is of fundamental importance in understanding the behavior of preparative chromatographic separation. This work describes the nonlinear binary protein adsorption equilibria on ion exchangers by the statistical thermodynamic (ST) model. The single-component and binary protein adsorption isotherms of bovine hemoglobin (Hb) and bovine serum albumin (BSA) on SP Sepharose FF were determined by batch adsorption experiments in 0.05 mol/L sodium acetate buffer at three pH values (4.5, 5.0 and 5.5) and three NaCl concentrations (0.05, 0.10 and 0.15 mol/L) at pH 5.0. The ST model was found to depict the effects of pH and ionic strength on the single-component equilibria well, with model parameters depending on the pH and ionic strength. Moreover, the ST model gave acceptable fitting to the binary adsorption data with the fitted single-component model parameters, leading to the estimation of the binary ST model parameter. The effects of pH and ionic strength on the model parameters are reasonably interpreted by the electrostatic and thermodynamic theories. Results demonstrate the availability of the ST model for describing nonlinear competitive protein adsorption equilibria in the presence of two proteins.

关键词： fundamental importance     single-component equilibria     acceptable fitting     hemoglobin     chromatographic separation    

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A neural network-based production process modeling and variable importance analysis approach in corn

《化学科学与工程前沿（英文）》 2023年 第17卷 第3期   页码 358-371 doi: 10.1007/s11705-022-2190-y

摘要： Corn to sugar process has long faced the risks of high energy consumption and thin profits. However, it’s hard to upgrade or optimize the process based on mechanism unit operation models due to the high complexity of the related processes. Big data technology provides a promising solution as its ability to turn huge amounts of data into insights for operational decisions. In this paper, a neural network-based production process modeling and variable importance analysis approach is proposed for corn to sugar processes, which contains data preprocessing, dimensionality reduction, multilayer perceptron/convolutional neural network/recurrent neural network based modeling and extended weights connection method. In the established model, dextrose equivalent value is selected as the output, and 654 sites from the DCS system are selected as the inputs. LASSO analysis is first applied to reduce the data dimension to 155, then the inputs are dimensionalized to 50 by means of genetic algorithm optimization. Ultimately, variable importance analysis is carried out by the extended weight connection method, and 20 of the most important sites are selected for each neural network. The results indicate that the multilayer perceptron and recurrent neural network models have a relative error of less than 0.1%, which have a better prediction result than other models, and the 20 most important sites selected have better explicable performance. The major contributions derived from this work are of significant aid in process simulation model with high accuracy and process optimization based on the selected most important sites to maintain high quality and stable production for corn to sugar processes.

关键词： big data     corn to sugar factory     neural network     variable importance analysis    

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The critical importance of epigenetics in autoimmune-related skin diseases

《医学前沿（英文）》 2023年 第17卷 第1期   页码 43-57 doi: 10.1007/s11684-022-0980-8

摘要： Autoimmune-related skin diseases are a group of disorders with diverse etiology and pathophysiology involved in autoimmunity. Genetics and environmental factors may contribute to the development of these autoimmune disorders. Although the etiology and pathogenesis of these disorders are poorly understood, environmental variables that induce aberrant epigenetic regulations may provide some insights. Epigenetics is the study of heritable mechanisms that regulate gene expression without changing DNA sequences. The most important epigenetic mechanisms are DNA methylation, histone modification, and noncoding RNAs. In this review, we discuss the most recent findings regarding the function of epigenetic mechanisms in autoimmune-related skin disorders, including systemic lupus erythematosus, bullous skin diseases, psoriasis, and systemic sclerosis. These findings will expand our understanding and highlight the possible clinical applications of precision epigenetics approaches.

关键词： epigenetics     autoimmune-related skin diseases     DNA methylation     histone modifications     noncoding RNAs    

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Recent advances in system reliability optimization driven by importance measures

Shubin SI, Jiangbin ZHAO, Zhiqiang CAI, Hongyan DUI

《工程管理前沿（英文）》 2020年 第7卷 第3期   页码 335-358 doi: 10.1007/s42524-020-0112-6

摘要： System reliability optimization problems have been widely discussed to maximize system reliability with resource constraints. Birnbaum importance is a well-known method for evaluating the effect of component reliability on system reliability. Many importance measures (IMs) are extended for binary, multistate, and continuous systems from different aspects based on the Birnbaum importance. Recently, these IMs have been applied in allocating limited resources to the component to maximize system performance. Therefore, the significance of Birnbaum importance is illustrated from the perspective of probability principle and gradient geometrical sense. Furthermore, the equations of various extended IMs are provided subsequently. The rules for simple optimization problems are summarized to enhance system reliability by using ranking or heuristic methods based on IMs. The importance-based optimization algorithms for complex or large-scale systems are generalized to obtain remarkable solutions by using IM-based local search or simplification methods. Furthermore, a general framework driven by IM is developed to solve optimization problems. Finally, some challenges in system reliability optimization that need to be solved in the future are presented.

关键词： importance measure     system performance     reliability optimization     optimization rules     optimization algorithms    

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The fundamental theory of traditional Chinese medicine and the consideration in its research strategy

Zhenji Li, Chunbo Xu

《医学前沿（英文）》 2011年 第5卷 第2期   页码 208-211 doi: 10.1007/s11684-011-0126-x

摘要： Stressing the uniqueness and complexity of traditional Chinese medicine (TCM) theory system, this paper analyzes the characteristics of TCM as a discipline from four perspectives: scientific nature, fundamental theory, clinical practice, and pharmacological action. It suggests that when the research strategy of TCM theory is designed, the core theory of TCM should be emphasized on the theoretical research on TCM original thinking theory, TCM theory, Chinese materia medica and formulas, acupuncture and moxibustion, meridians and collaterals, and other related fields. Researchers and practitioners should ensure that the basic research on TCM theory is based on clinical practice, research methods (both traditional and contemporary) are exploited, and methodological innovation is underscored. The rule of TCM development should be followed and the characteristics and advantages of TCM carried forward. Meanwhile, the methods and theory of contemporary science and technology should be exploited to fulfill the goal of inheriting, enriching, and developing the fundamental theory of TCM.

关键词： fundamental theory     traditional Chinese medicine     research strategy    

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From systematicness to complexity: Fundamental thinking of mega-project management

Zhaohan SHENG, Han LIN

《工程管理前沿（英文）》 2018年 第5卷 第1期   页码 125-127 doi: 10.15302/J-FEM-2018001

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Improved resilience measure for component recovery priority in power grids

《工程管理前沿（英文）》 2021年 第8卷 第4期   页码 545-556 doi: 10.1007/s42524-021-0161-5

摘要： Given the complexity of power grids, the failure of any component may cause large-scale economic losses. Consequently, the quick recovery of power grids after disasters has become a new research direction. Considering the severity of power grid disasters, an improved power grid resilience measure and its corresponding importance measures are proposed. The recovery priority of failed components after a disaster is determined according to the influence of the failed components on the power grid resilience. Finally, based on the data from the 2019 Power Yearbook of each city in Shandong Province, China, the power grid resilience after a disaster is analyzed for two situations, namely, partial components failure and failure of all components. Result shows that the recovery priorities of components with different importance measures vary. The resilience evaluations under different repair conditions prove the feasibility of the proposed method.

关键词： resilience measure     power grid     importance measure     component recovery    

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balloon-only strategy for percutaneous coronary intervention of left main coronary artery disease: the importance

《医学前沿（英文）》 2023年 第17卷 第1期   页码 75-84 doi: 10.1007/s11684-022-0950-1

摘要： This retrospective single-center registry study included all consecutive patients who underwent percutaneous coronary intervention (PCI) for a de novo left main coronary artery lesion using drug coated-balloon (DCB)-only strategy between August 2011 and December 2018. To best of our knowledge, no previous studies of DCB-only strategy of treating de novo left main coronary artery disease, exist. The primary endpoint was major adverse cardiovascular events (MACEs) including cardiac death, non-fatal myocardial infarction, and target lesion revascularization (TLR). The cohort was divided into two groups depending on weather the lesion preparation was done according to the international consensus group guidelines. Sixty-six patients (mean age 75±8.6, 72% male), 52% of whom had acute coronary syndrome, underwent left main PCI with the DCB-only strategy. No procedural mortality and no acute closures of the treated left main occurred. At 12 months, MACE and TLR occurred in 24% and 6% of the whole cohort, respectively. If the lesion preparation was done according to the guidelines, the MACE and TLR rates were 21.2% and 1.9%. Left main PCI with the DCB only-strategy is safe leading to acceptable MACE and low TLR rates at one year, if the lesion preparation is done according to the guidelines.

关键词： drug-coated balloon     left main     high bleeding risk     predilatation     calcifield lesion     percutaneous coronary intervention    

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Conformal analysis of fundamental frequency of vibration of elastic clamped plates

QI Hongyuan, ZHU Hengjun

《机械工程前沿（英文）》 2007年 第2卷 第4期   页码 429-432 doi: 10.1007/s11465-007-0073-z

摘要： To calculate the fundamental frequency of vibration of special-shaped and elastic clamped plates, the conformal mapping theory is adopted to separate the interpolating points of a complicated boundary into odd and even sequences, both of which can be mutually iterated, so that the conformal mapping function between the complicated region and the unit dish region is established. Trigonometric interpolation and convergence along the normal direction methods are provided, and the complex coefficients of the conformal mapping function are calculated. Galerkin method is used to obtain the solution of fundamental frequency in the vibrating differential function of the complicated vibrating region. Finally, taking ellipse elastic clamped plates as an example, the effects on fundamental frequency coefficient caused by eccentric ratio and area size are analyzed.

关键词： direction     theory     vibration     odd     complicated boundary    

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精密工程的重要性日益增加

Mark Hoffman, Liangchi Zhang

《工程（英文）》 2018年 第4卷 第6期   页码 759-759 doi: 10.1016/j.eng.2018.11.007

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Level set-based isogeometric topology optimization for maximizing fundamental eigenfrequency

Manman XU, Shuting WANG, Xianda XIE

《机械工程前沿（英文）》 2019年 第14卷 第2期   页码 222-234 doi: 10.1007/s11465-019-0534-1

摘要： Maximizing the fundamental eigenfrequency is an efficient means for vibrating structures to avoid resonance and noises. In this study, we develop an isogeometric analysis (IGA)-based level set model for the formulation and solution of topology optimization in cases with maximum eigenfrequency. The proposed method is based on a combination of level set method and IGA technique, which uses the non-uniform rational B-spline (NURBS), description of geometry, to perform analysis. The same NURBS is used for geometry representation, but also for IGA-based dynamic analysis and parameterization of the level set surface, that is, the level set function. The method is applied to topology optimization problems of maximizing the fundamental eigenfrequency for a given amount of material. A modal track method, that monitors a single target eigenmode is employed to prevent the exchange of eigenmode order number in eigenfrequency optimization. The validity and efficiency of the proposed method are illustrated by benchmark examples.

关键词： topology optimization     level set method     isogeometric analysis     eigenfrequency    

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基于网络传输特性的链路重要性评价方法

姜禹,胡爱群,何明

《中国工程科学》 2009年 第11卷 第9期   页码 64-67

摘要：

提出了一种基于网络传输特性的链路重要性评价方法, 根据链路在网络所有节点相互通信的最短路径中的使用频度来评价链路重要性，最重要链路的使用频度最高。该方法不需要像目前的链路重要性评价方法那样进行链路收缩和删除，直接反映了链路对整个网络通信的贡献大小，可以判断通信网中任意两条链路的相对重要性。算法分析和实验仿真表明，文章算法克服了目前的评价方法存在的问题，给出了更直观合理的通信网链路重要性评价准则。

关键词： 通信网     链路重要性     最短路径     串联链路    

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Fundamental influences of particles on stirred and unstirred venting processes of foaming systems

Henrik LEIMEISTER,Jörg STEINBACH

《化学科学与工程前沿（英文）》 2014年 第8卷 第2期   页码 141-148 doi: 10.1007/s11705-014-1423-0

摘要： Venting is the common safety measure to protect plant equipment against excessive overpressure. So far, scenarios in which particles were part of the system and should have been accounted for did ignore their presence; the scenarios were treated like a two-phase system. Current research shows that particles can have a major influence on the venting behaviour. Experimental results indicate that particles affect level swell and relief flow especially of foamy systems. Based on those results four different layers of influence of the particle have been identified and are presented in a first model. Based on this model recommendations for the development of new and more complex models are given.

关键词： venting     multi-phase    

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Emergy evaluation of polygeneration systems

WANG Lingmei, LI Zheng, NI Weidou

《能源前沿（英文）》 2007年 第1卷 第2期   页码 223-227 doi: 10.1007/s00000-007-0030-x

摘要： To expand the application range of the emergy evaluation method, an emergy evaluation index, which can reflect the particular feature of polygeneration systems, has been elaborated on the basis of energy and emergy conservation, guided by the fundamental principle of emergy analysis. With this index, the cost structure, emission effect and energy saved were all considered on the same level of importance. To exemplify, some power polygeneration systems (methanol-power generation, hydrogen-power generation) are considered using coal as the basic fuel. The results showed that emergy evaluation indices are practical for comprehensively evaluating polygeneration systems and their sustainability, which is influenced by such factors as the joining mode of polygeneration and the technologies used. The sustainability of polygeneration systems, which work on an appropriate ratio of fuel-to-electric power basis, is higher than that of singular production systems.

关键词： fuel-to-electric     sustainability     importance     polygeneration     practical    

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基于重要性采样的TOA与FOA无源定位算法 Article

Rui-rui LIU, Yun-long WANG, Jie-xin YIN, Ding WANG, Ying WU

《信息与电子工程前沿（英文）》 2017年 第18卷 第8期   页码 1167-1179 doi: 10.1631/FITEE.1601657

摘要： 最大似然类的无源定位方法可以达到较高的定位精度，但其计算量非常大。由于时频参数联合定位模型本身的非线性和非凸性非常大，繁重的计算量在TOA与FOA联合定位系统中表现尤为明显。本文针对这一问题，通过Pincus全局最优理论和蒙特卡洛重要性采样技术降低了最大似然类定位算法的计算复杂度，并且保证算法可以收敛到全局最优解。本文主要的贡献是构建了一个高斯分布的概率密度函数来近似原始的代价函数方便后续的采样，我们称之为重要性函数。该方法所带来性能上的提升是因为选择了最优的重要性函数并且Pincus保证算法收敛到全局最小值。这一处理大大降低了计算量，由于算法进行了泰勒级数展开，需要初始估计值。通过采样处理并且对样本进行加权，本文算法对初始估计值具有良好的鲁棒性。最后，实验证明本文所提算法可以达到克拉美罗限，且性能要优于现有算法。

关键词： 无源定位；到达时间；到达频率；蒙特卡洛重要性采样；最大似然估计    

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标题 作者 时间 类型 操作

Analysis of statistical thermodynamic model for binary protein adsorption equilibria on cation exchange adsorbent

ZHOU Xiaopeng, SU Xueli, SUN Yan

期刊论文

A neural network-based production process modeling and variable importance analysis approach in corn

期刊论文

The critical importance of epigenetics in autoimmune-related skin diseases

期刊论文

Recent advances in system reliability optimization driven by importance measures

Shubin SI, Jiangbin ZHAO, Zhiqiang CAI, Hongyan DUI

期刊论文

The fundamental theory of traditional Chinese medicine and the consideration in its research strategy

Zhenji Li, Chunbo Xu

期刊论文

From systematicness to complexity: Fundamental thinking of mega-project management

Zhaohan SHENG, Han LIN

期刊论文

Improved resilience measure for component recovery priority in power grids

期刊论文

balloon-only strategy for percutaneous coronary intervention of left main coronary artery disease: the importance

期刊论文

Conformal analysis of fundamental frequency of vibration of elastic clamped plates

QI Hongyuan, ZHU Hengjun

期刊论文

精密工程的重要性日益增加

Mark Hoffman, Liangchi Zhang

期刊论文

Level set-based isogeometric topology optimization for maximizing fundamental eigenfrequency

Manman XU, Shuting WANG, Xianda XIE

期刊论文

基于网络传输特性的链路重要性评价方法

姜禹,胡爱群,何明

期刊论文

Fundamental influences of particles on stirred and unstirred venting processes of foaming systems

Henrik LEIMEISTER,Jörg STEINBACH

期刊论文

Emergy evaluation of polygeneration systems

WANG Lingmei, LI Zheng, NI Weidou

期刊论文

基于重要性采样的TOA与FOA无源定位算法

Rui-rui LIU, Yun-long WANG, Jie-xin YIN, Ding WANG, Ying WU

期刊论文